Greetings!
Yes, I would also quarantine a new arrival: Especially if it is going into bioactive. You want to find any issues beforehand.
If you can set up a separate secured enclosure with a thermostat and heating element–that would be ideal. Paper towels as substrate until you confirm there are no hitchhikers or suspicious fluid discharge (nostrils, mouth, vent). IMHO: Feeding routine and preference should also be set and imprinted before you provide a highly varied environment to a snake that could potentially be a picky eater.
I’m not sure the size of your bioactive enclosure…none of my planted bioactive enclosures could handle an adult ball python indefinitely. They are like small bulldozers that drive around and can periodically produce some serious amounts of waste… I know a lot of people like to start off with bioactive, but it often becomes less feasible as the snake grows larger. 
